Short Courses

Short courses are available the Sunday preceding the meeting.

Short Course I
Chiroptical Spectroscopy Basic principles and Recent Advances in Experimental and Theoretical Chiroptical Spectroscopic Methods (ECD, ORD, VCD and ROA) for the Determination of Stereochemical Molecular and Supramolecular Structures

Nina Berova - Columbia University, USA
Gennaro Pescitelli - Università di Pisa, Italy
Prasad Polavarapu - Vanderbilt University, USA

Chiroptical spectroscopies – Electronic Circular Dichroism (ECD), Vibrational CD (VCD), Raman Optical Activity (ROA) and optical Optical Rotatory Dispersion (ORD) – are a family of very efficient and sensitive tools for determining the molecular and supramolecular structures. In this short course, the basics, theory and applications of modern chiroptical spectroscopies, in combination with quantum chemistry computational methods, will be presented. Several examples (ranging from small organic molecules to natural products and biopolymers) from the recent literature will illustrate the use of these methods to solve different stereochemical problems, such as the assignment of absolute configurations and structure elucidation of supramolecular assemblies. It is assumed that all participants have a basic knowledge on organic chemistry and molecular spectroscopy.

Biographical Sketch:

Nina Berova is currently Research and Adjunct Professor in the Department of Chemistry at Columbia University, New York. Her research is focused on organic stereochemistry and structural analysis of synthetic compounds and natural products, in particular, by chiroptical spectroscopy. She has over 220 publications and has been recipient of many scholarships, visiting professorships, and of prestigious awards specifically for her studies on chirality. Since 1998-present she is a co-Editor of Journal “Chirality.

Nina Berova is also a co-editor and co-author of a few previous monographs on Circular Dichroism (1994 and 2000), and of the most recent two-volume monograph “Comprehensive Chiroptical Spectroscopy” (2012) by John Wiley & Sons. 

Gennaro Pescitelli received his PhD (2001) degree in Chemistry from the University of Pisa, and is Associate Professor of Organic Chemistry at the same University. He is co-author of about 140 publications, including a series of tutorial reviews about the basics and applications of ECD published by Chemical Society Reviews together with Nina Berova and Lorenzo Di Bari. His research is focused on spectroscopic and computational investigations of chiral organic molecules, especially natural products, metal-based catalysts, organic crystals, organo-gelators and functional polymers.                                                                             

Prasad Polavarapu is Professor of Chemistry at Vanderbilt University, USA. He published over 260 peer reviewed research papers and is the author/editor of multiple books. His latest book “Chiroptical spectroscopy: Fundamentals and Applications” is scheduled to be released this summer. Professor Polavarapu was elected as a 2012 Fellow of the American Association for the Advancement of Science for distinguished contributions to the field of chiral molecular structure determination. He is also the recipient of 2010 Jeffrey Nordhaus Award for excellence in undergraduate teaching at Vanderbilt University. The first quantum chemical predictions of specific rotation, and of vibrational Raman optical activity

 

 

Short Course II
Chiral Separations

Daniel W. Armstrong & Zachary Breitbach
University of Texas at Arlington

The goal of the “chiral separations” short course is to familiarize the participants with the best available options when confronted with the need for chiral separations. The course format allows for the dissemination of a considerable amount of information in an interesting and informal manner. Attendees can expect to gain an in-depth knowledge of chirality, the different means to separate enantiomers, and when / how to apply different state-of-the-art techniques. There will be a question and answer session at the conclusion of the course and participants are encouraged to ask any question related to the course as well as discuss current chiral separations challenges in their laboratory. Course outline: The first part of the course will include a review of the terminology of chirality and a brief overview of the theory behind enantiomeric separations (30 min). Then a summary of all HPLC techniques will be presented (70 min). The second half of the course will focus on new HPLC chiral selectors and method development (60 min) with a final focus on supercritical fluid (SFC) separations (40 min). The last discussion topic will cover capillary based enantiomeric separations by GC and CE (30 min).

Target Audience: The course is designed for researchers faced with separation or analysis of enantiomeric compounds. The material is broadly applicable and useful for researchers in industry (e.g. pharmaceutical, agrochemical, etc…), as well as, academic researchers. Participants should have a basic knowledge of chromatography and experience with routine achiral GC and HPLC.

Biographical Sketch:

Daniel W. Armstrong is the Robert A. Welch Professor of Chemistry at the University of Texas at Arlington.   He has over 550 publications including 29 book chapters, one book ("Use of Ordered Media in Chemical Separations") and 23 patents.   He is considered the "Father" of pseudophase (micelle and cyclodextrin-based) separations.  He elucidated the first chiral recognition mechanism for cyclodextrins.  He also first developed macrocyclic antibiotics and cyclofructans as chiral selectors.  He is one of the world's leading authorities on the theory, mechanism and use of enantioselective molecular interactions

Zachary Breitbach obtained his Bachelor of Science degree in chemistry from Clarke College in 2005.  He received his Doctor of Philosophy degree in analytical chemistry from The University of Texas at Arlington under the direction of Professor Daniel Armstrong in 2010. He continued his career at UTA serving as a Research Scientist where he helped develop new chiral stationary phases for HPLC, SFC and GC.  He also serves as a consultant to AZYP, LLC regarding new chemical separation media focused on chiral and HILIC HPLC separations.  He has published more than 50 peer-reviewed research manuscripts, holds 3 patents, and has presented work at numerous research conferences.